Week 1 Nfl Predictions 2025 Espn Predictions. 9 new york jets at san francisco 49ers, 5:15 p.m., espn,. Visit sportsline now to get eric cohen's nfl week 1 score predictions, all from the nfl.
Read our expert analysis and predictions before placing your week 1 bets! The week 1 nfl schedule for the 2025 season is stacked with great matchups, and we’ve got you covered with what you need to know heading into the weekend.